Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma

Autor: Mark Manzano, Ajinkya Patil, Alexander Waldrop, Sandeep S. Dave, Amir Behdad, Eva Gottwein
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-018-05506-9
Popis: Our understanding of the genetics and treatment options for primary effusion lymphoma (PEL) is lacking. Here the authors performed in vitro CRISPR/Cas9 knock-out screens to identify 210 PEL-specific oncogenic genes and report strategies for therapeutic intervention.
Databáze: Directory of Open Access Journals