New biological model of moderate inhibition of tumor and metastases growth with prolonged leukopenia in mice
| Autor: | O. Y. Rybalkina, N. N. Ermakova, T. G. Razina, E. G. Skurikhin, E. P. Zueva |
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| Jazyk: | ruština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Acta Biomedica Scientifica, Vol 1, Iss 5, Pp 121-125 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2541-9420 2587-9596 |
| DOI: | 10.12737/23406 |
| Popis: | A new biological model of moderate inhibition of tumor growth and metastases with prolonged leukopenia on C57BI/6 mice with the Lewis Lung Carcinoma was designed. The model was created by the injection of cyclophosphamide (dose 83.3 mg/kg) on 6th, 12th, 18th days after tumor cells transplantation on animals. Experiment showed that 3-fold cyclophosphamide use leads to growth of primary tumor and metastases inhibition. Tumor growth inhibition was 34 % on 21st day after cyclophosphamide inject. The number of metastases decreased by 4.7 times (p < 0,01). Metastatic area reduced. Metastasis frequency made 100 %. In addition, the course of cyclophosphamide application caused inhibition of granulocytic and lymphoid hematopoiesis. The reducing the number of segmented neutrophils and lymphocytes was showed on the 3rd day after 1, 2 and 3 injections of cyclophosphamide. The model can be used to study the efficacy of drugs in tumor therapy and in correction of such toxic manifestation of chemotherapy as leukopenia. |
| Databáze: | Directory of Open Access Journals |
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