Association of rs16953002 FTO Gene Polymorphism with Type 2 Diabetes and Obesity
| Autor: | mohammad bakhshi ganje, mohamad hassan shekhha, ehsan farashahi, morteza mohammadzade |
|---|---|
| Jazyk: | perština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Journal of Fasa University of Medical Sciences, Vol 6, Iss 1, Pp 27-34 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2228-5105 2228-7329 |
| Popis: | Background & Objective: Genome-wide association studies (GWAS) has identified that FTO gene polymorphisms was associated with the risk of type 2 diabetes and obesity. However, the findings in subsequent studies were inconsistent in various populations. This study aimed to investigate the association of FTO rs16953002 with type 2 diabetes and obesity in Yazd, Iran. Methods & Materials: Unrelated study subject controls (n=200) and type 2 diabetes cases (T2DM) (n=200), were randomly selected from Yazd, Iran. Genotyping was done by the polymerase chain reaction-restriction fragment length polymorphism method. Age and gender, smoking, weight and body mass index (BMI) were analyzed using the analysis of χ2 test. Results: The rs16953002 A/G polymorphism of the FTO gene showed significant association with T2DM and obesity. The AG, GG genotypes were significantly higher in T2DM and obese subjects compared to the group subjects. Conclusions: The result of the present study indicate that the genetic variant in FTO may contribute to T2DM and obesity risk in Yazd population. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|