Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization

Autor: Chih-Chan Lee, Jiunn-Chang Lin, Wei-Lun Hwang, Ying-Ju Kuo, Hung-Kai Chen, Shyh-Kuan Tai, Chun-Chi Lin, Muh-Hwa Yang
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-018-06268-0
Popis: Tumor microenvironment varies between primary and metastatic sites. Here they report tumor-associated macrophages from metastatic sites to be predominantly M2 type, and secrete IL-35 to promote metastasis through activation of JAK2–STAT6–GATA3 signaling.
Databáze: Directory of Open Access Journals