Surgical site peptidylarginine deaminase 4 (PAD4), a biomarker of NETosis, correlates with insulin resistance in total joint arthroplasty patients: A preliminary report.

Autor:	Vitor F Martins, Christopher R Dobson, Maedha Begur, Jesal Parekh, Scott T Ball, Francis Gonzalez, Jan M Hughes-Austin, Simon Schenk
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Medicine Science
Zdroj:	PLoS ONE, Vol 16, Iss 1, p e0245594 (2021)
Druh dokumentu:	article
ISSN:	1932-6203
DOI:	10.1371/journal.pone.0245594
Popis:	While obesity and insulin resistance are known risk factors for wound complications after total joint arthroplasty (TJA), the biologic causes remain to be elucidated. Recently, neutrophil extracellular trap formation (NETosis) was identified as a mediator of delayed wound healing in insulin resistant states. Herein, we explored the relationship between obesity, insulin resistance and biomarkers of NET formation in TJA subjects. We enrolled 14 obese (body mass index [BMI]≥30 kg/m2), and 15 lean (BMI
Databáze:	Directory of Open Access Journals
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