Widespread existence of uncorrelated probe intensities from within the same probeset on Affymetrix GeneChips

Autor: Sanchez-Graillet Olivia, Rowsell Joanna, Langdon William B., Stalteri Maria, Arteaga-Salas Jose M., Upton Graham J. G., Harrison Andrew P.
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Zdroj: Journal of Integrative Bioinformatics, Vol 5, Iss 2, Pp 104-116 (2008)
Druh dokumentu: article
ISSN: 1613-4516
DOI: 10.1515/jib-2008-98
Popis: We have developed a computational pipeline to analyse large surveys of A ymetrix GeneChips, for example NCBI’s Gene Expression Omnibus. GEO samples data for many organisms, tissues and phenotypes. Because of this experimental diversity, any observed correlations between probe intensities can be associated either with biology that is robust, such as common co-expression, or with systematic biases associated with the GeneChip technology.
Databáze: Directory of Open Access Journals