Children as sentinels of tuberculosis transmission: disease mapping of programmatic data

Autor: Kenneth S. Gunasekera, Jon Zelner, Mercedes C. Becerra, Carmen Contreras, Molly F. Franke, Leonid Lecca, Megan B. Murray, Joshua L. Warren, Ted Cohen
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: BMC Medicine, Vol 18, Iss 1, Pp 1-7 (2020)
Druh dokumentu: article
ISSN: 1741-7015
DOI: 10.1186/s12916-020-01702-x
Popis: Abstract Background Identifying hotspots of tuberculosis transmission can inform spatially targeted active case-finding interventions. While national tuberculosis programs maintain notification registers which represent a potential source of data to investigate transmission patterns, high local tuberculosis incidence may not provide a reliable signal for transmission because the population distribution of covariates affecting susceptibility and disease progression may confound the relationship between tuberculosis incidence and transmission. Child cases of tuberculosis and other endemic infectious disease have been observed to provide a signal of their transmission intensity. We assessed whether local overrepresentation of child cases in tuberculosis notification data corresponds to areas where recent transmission events are concentrated. Methods We visualized spatial clustering of children
Databáze: Directory of Open Access Journals
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