| Autor: |
Nermeen Bastawy, Ghada Farouk Soliman, Nermeen Bakr Sadek, Doaa Mostafa Gharib, Mai Abdelaziz Gouda, Laila Ahmed Rashed, Hanan Abdallah, Dina Hisham, Omnia Mohamed Abdel-Maksoud |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Beni-Suef University Journal of Basic and Applied Sciences, Vol 13, Iss 1, Pp 1-12 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2314-8543 |
| DOI: |
10.1186/s43088-024-00548-z |
| Popis: |
Abstract Background High fat-fructose diet is a proinflammatory diet that increases risk of hepatocytes and myocytes steatosis and fibrosis. Finding anti-inflammatory strategies to fight these harmful effects is paid attention to nowadays. This study compared the effects of two widely anti-inflammatory interventions—metformin and intermittent fasting on myocytes and hepatocyte injury induced by proinflammatory diet and tracking possible underlying mechanisms. In this work, rats fed high fat-fructose diet were subdivided into untreated group, treated by metformin, and/or intermittent fasting. Results Metformin (300 mg/kg/day) and intermittent fasting (3 days/week) specially their combination for 4 weeks showed significant improvement in insulin resistance, lipid profile, antioxidants (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink