Changes in the haematological parameters of HIV-1 infected children at 6 and 12 months of antiretroviral therapy in a large clinic cohort, North-Central Nigeria

Autor: Augustine O. Ebonyi, Stephen Oguche, Martha O. Ochoga, Oche O. Agbaji, Joseph A. Anejo-Okopi, Isaac O. Abah, Prosper I. Okonkwo, John A. Idoko
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Journal of Virus Eradication, Vol 3, Iss 4, Pp 208-211 (2017)
Druh dokumentu: article
ISSN: 2055-6640
DOI: 10.1016/S2055-6640(20)30315-0
Popis: Background: Prior to commencing antiretroviral therapy (ART), haematological abnormalities are a common occurrence in individuals diagnosed with human immunodeficiency virus (HIV). In the course of receiving ART, these abnormalities usually improve. We determined the prevalence of haematological abnormalities in children diagnosed with HIV-1 and the changes in haematological parameters that occur after 6 and 12 months of being on ART. Methods: A cross-sectional study of HIV-1 infected children aged 2 months to 15 years, between July 2005 and March 2013, at the paediatric HIV clinic of the Jos University Teaching Hospital, Jos. Median values of repeated measures were compared using the Wilcoxon signed-rank sum test. Results: The prevalence of anaemia, thrombocytopenia and leukopenia among the 941 children studied, prior to ART was 6.4%, 7.0% and 8.6%. Median (IQR) haemoglobin (Hb) levels increased from 10 g/dL (9–11 g/dL) at baseline to 11 g/dL (10–12 g/dL) and 11 g/dL (10–12 g/dL) at 6 and 12 months of ART (P
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