MAC-spinal meningioma score: A proposal for a quick-to-use scoring sheet of the MIB-1 index in sporadic spinal meningiomas

Autor:	Johannes Wach, Motaz Hamed, Tim Lampmann, Ági Güresir, Frederic Carsten Schmeel, Albert J. Becker, Ulrich Herrlinger, Hartmut Vatter, Erdem Güresir
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	MIB-1 (Ki-67 labeling) index score spinal meningioma proliferation clinical implications Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Frontiers in Oncology, Vol 12 (2022)
Druh dokumentu:	article
ISSN:	2234-943X
DOI:	10.3389/fonc.2022.966581
Popis:	ObjectiveMIB-1 index is an important predictor of meningioma progression. However, MIB-1 index is not available in the preoperative tailored medical decision-making process. A preoperative scoring sheet independently estimating MIB-1 indices in spinal meningioma (SM) patients has not been investigated so far.MethodsBetween 2000 and 2020, 128 patients with clinical data, tumor imaging data, inflammatory laboratory (plasma fibrinogen, serum C-reactive protein) data, and neuropathological reports (MIB-1, mitotic count, CD68 staining) underwent surgery for spinal WHO grade 1 and 2 meningioma.ResultsAn optimal MIB-1 index cut-off value (≥5/
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a470dceb5b334c809d53c754fe453cc3 Zobrazit plný text záznamu View record in DOAJ