The marker of alkyl DNA base damage, N7-methylguanine, is associated with semen quality in men

Autor:	B. Altakroni, C. Nevin, M. Carroll, C. Murgatroyd, G. Horne, D. R. Brison, A. C. Povey
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Medicine Science
Zdroj:	Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-021-81674-x
Popis:	Abstract Sperm DNA contains a range of DNA base damage that can arise, in part, from exposure to methylating agents. However, the effects are not fully characterized and so the aim of this study was to investigate associations between semen quality and the levels of N7-methyldeoxyguanosine (N7-MedG), a marker of exposure to methylating agents, and other markers of DNA damage and DNA methylation. Sperm samples were collected from 105 men attending an assisted reproduction clinic as part of a couple undergoing treatment for infertility and semen quality assessed manually according to WHO guidelines. Semen levels of N7-MedG, quantified by immunoslotblot, were significantly higher in men with sperm concentration
Databáze:	Directory of Open Access Journals
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