Antibacterial Polysiloxane Polymers and Coatings for Cochlear Implants
| Autor: | Vlad Cozma, Irina Rosca, Luminita Radulescu, Cristian Martu, Valentin Nastasa, Cristian-Dragos Varganici, Elena-Laura Ursu, Florica Doroftei, Mariana Pinteala, Carmen Racles |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Molecules, Vol 26, Iss 16, p 4892 (2021) |
| Druh dokumentu: | article |
| ISSN: | 26164892 1420-3049 |
| DOI: | 10.3390/molecules26164892 |
| Popis: | Within this study, new materials were synthesized and characterized based on polysiloxane modified with different ratios of N-acetyl-l-cysteine (NAC) and crosslinked via UV-assisted thiol-ene addition, in order to obtain efficient membranes able to resist bacterial adherence and biofilm formation. These membranes were subjected to in vitro testing for microbial adherence against S. pneumoniae using standardized tests. WISTAR rats were implanted for 4 weeks with crosslinked siloxane samples without and with NAC. A set of physical characterization methods was employed to assess the chemical structure and morphological aspects of the new synthetized materials before and after contact with the microbiological medium. |
| Databáze: | Directory of Open Access Journals |
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