The Role of the Caudate in Nonmotor Behaviors in Huntington’s Disease

Autor: D. H. Jacobs, S. J. Huber
Jazyk: angličtina
Rok vydání: 1992
Předmět:
Zdroj: Behavioural Neurology, Vol 5, Iss 4, Pp 205-214 (1992)
Druh dokumentu: article
ISSN: 0953-4180
1875-8584
DOI: 10.3233/BEN-1992-5402
Popis: Neuropsychologic data suggest an important role for the caudate nucleus (CN) in behavioral impairments in Huntington's disease (HD). These include abnormalities in executive function, egocentric visuospatial representations, communication, and retrieval of declarative memories, changes in personality, and psychiatric disturbances. Animal paradigms of CN lesions support a role for the CN in some of these behaviors. Current theories of basal ganglia function add explanatory value to the role of the CN in these behaviors. A disconnection of the caudate from limbic structures, including the amygdala may account for many nonmotor behaviors observed in HD.
Databáze: Directory of Open Access Journals
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