Treatment of pseudobulbar affect in a mixed neurodegenerative disorder with compounded quinidine capsules and dextromethorphan cough syrup

Autor: Yannick Villeneuve, Diana Cruz-Santiago, Helene Masson, Doris Clerc
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: SAGE Open Medical Case Reports, Vol 8 (2020)
Druh dokumentu: article
ISSN: 2050-313X
2050313X
DOI: 10.1177/2050313X20921076
Popis: An elderly woman admitted in our geriatric inpatient unit suffered from disturbing outbursts of crying and, less frequently, episodes of laughing. The patient was diagnosed with pseudobulbar affect related to a mixed neurodegenerative disorder. This condition is often underdiagnosed and undertreated, despite being relatively frequent in patients with neurodegenerative disorders. This case report describes the treatment of pseudobulbar affect in this patient. The only available treatment in Canada for this condition, antidepressants, was not effective for our patient. Dextromethorphan/quinidine is a good accepted alternative, but the combination is not marketed in Canada. To manage this problem, we used compounded quinidine capsules and dextromethorphan cough syrup. The crying of our patient improved significantly and rapidly after the initiation of this treatment. This case will help professionals to review their central role in treating this complex and disabling condition.
Databáze: Directory of Open Access Journals