Conserved transcriptomic profile between mouse and human colitis allows unsupervised patient stratification

Autor: Paulo Czarnewski, Sara M. Parigi, Chiara Sorini, Oscar E. Diaz, Srustidhar Das, Nicola Gagliani, Eduardo J. Villablanca
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-10769-x
Popis: Clinical and molecular heterogeneity of ulcerative colitis presents unresolved challenges to identify predictive biomarkers of response to therapies. Here, the authors combine mouse colitis time course with patient biopsy transcriptomes, achieving unsupervised clustering of UC patients correlating with therapeutic outcomes in independent data sets.
Databáze: Directory of Open Access Journals