Autor: |
Bunthen E, Ko Ko, Rattana Kim, Shintaro Nagashima, Serge Ouoba, Md Razeen Ashraf Hussain, Tomoki Sato, Channarena Chuon, Kanon Abe, Aya Sugiyama, Kazuaki Takahashi, Tomoyuki Akita, Rathavy Tung, Vichit Ork, Md. Shafiqul Hossain, Vonthanak Saphonn, Junko Tanaka |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-12 (2023) |
Druh dokumentu: |
article |
ISSN: |
1471-2334 |
DOI: |
10.1186/s12879-023-08249-1 |
Popis: |
Abstract Background In countries with intermediate or high hepatitis B virus (HBV) endemicity, mother-to-child transmission (MTCT) represents the main route of chronic HBV infection. There is a paucity of information on HBV MTCT in Cambodia. This study aimed to investigate the prevalence of HBV infection among pregnant women and its MTCT rate in Siem Reap, Cambodia. Methods This longitudinal study included two parts, study-1 to screen HBsAg among pregnant women and study-2 to follow up babies of all HBsAg-positive and one-fourth of HBsAg-negative mothers at their delivery and six-month post-partum. Serum or dried blood spot (DBS) samples were collected to examine HBV sero-markers by chemiluminescent enzyme immunoassay (CLEIA), and molecular analyses were performed on HBsAg-positive samples. Structured questionnaires and medical records were used to examine the risk factors for HBV infection. MTCT rate was calculated by HBsAg positivity of 6-month-old babies born to HBsAg-positive mothers and ascertained by the homology of HBV genomes in mother–child pair at 6-month-old. Results A total of 1,565 pregnant women were screened, and HBsAg prevalence was 4.28% (67/1565). HBeAg positivity was 41.8% and was significantly associated with high viral load (p |
Databáze: |
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