Extramedullary haematopoiesis in patients with transfusion dependent β-thalassaemia (TDT): a systematic review
| Autor: | Eihab A. Subahi, Fateen Ata, Hassan Choudry, Phool Iqbal, Mousa A. AlHiyari, Ashraf T. Soliman, Vincenzo De Sanctis, Mohamed A. Yassin |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Annals of Medicine, Vol 54, Iss 1, Pp 764-774 (2022) |
| Druh dokumentu: | article |
| ISSN: | 07853890 1365-2060 0785-3890 |
| DOI: | 10.1080/07853890.2022.2048065 |
| Popis: | Introduction Around 5% of the world’s population is expected to have some degree and type of thalassaemia. Beta thalassaemia (BT) occurs due to a deficient production of the beta-globin chain of haemoglobin. Extramedullary haematopoiesis (EMH) is one of the complications of BT, mainly observed in minor/intermedia subtypes. EMH is the production of blood cells outside the marrow as a compensatory response to longstanding hypoxia. Due to chronic transfusions, it is not expected in patients with beta-thalassaemia major (BTM). However, there are increasingly reported cases of EMH in BTM. The incidence of EMH in BTM is thought to be |
| Databáze: | Directory of Open Access Journals |
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