| Autor: |
Hong Gao, Chaomin Yin, Chen Li, Yuhong Li, Defang Shi, Xiuzhi Fan, Fen Yao, Wenjing Wu, Jiangtao Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Current Research in Food Science, Vol 6, Iss , Pp 100519- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2665-9271 |
| DOI: |
10.1016/j.crfs.2023.100519 |
| Popis: |
In this study, phenolic-rich extracts from Sanghuangporus vaninii (SHE) were prepared, the phenolic profile and main phenolic compound content of SHE were studied by UPLC-Orbitrap-MS, and the antioxidant and antiproliferation activities of SHE were evaluated. The results showed that the total polyphenol content and the total flavonoid content of SHE were 42.420 ± 0.011 mg GAE/g EW and 8.504 ± 0.205 mg RE/g EW, respectively. Moreover, 14 phenolic acids and 8 flavonoids in SHE were identified, among which, the major polyphenols were protocatechualdehyde (394.68 μg/g), protocatechuic acid (196.88 μg/g), caffeic acid (96.11 μg/g), L-phenylalanine (12.72 μg/g) and (+)-taxifolin (8.59 μg/g). SHE showed strong radical scavenging, anti-lipid peroxidation and anti-DNA damage capacity in vitro. SHE could effectively induce HepG2 cell apoptosis via the caspases-dependent mitochondrial apoptotic pathway and arrest the cell cycle in the G0/G1 phase. The present study suggested that S. vaninii could be a valuable source of natural antioxidative and antiproliferative ingredients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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