p-Cymene Complexes of Ruthenium(II) as Antitumor Agents

Autor: María Angeles Pujante-Galián, Sergio A. Pérez, Mercedes G. Montalbán, Guzmán Carissimi, Marta G. Fuster, Gloria Víllora, Gabriel García
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Molecules, Vol 25, Iss 21, p 5063 (2020)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules25215063
Popis: In this work, the cytotoxic behavior of six ruthenium(II) complexes of stoichiometry [(η6-p-cymene)RuCl2L] (I-VI), L = 4-cyanopyridine (I), 2-aminophenol (II), 4-aminophenol (III), pyridazine (IV), and [(η6-p-cymene)RuClL2]PF6; L = cyanopyridine (V), L = 2-aminophenol(VI) towards three cell lines was studied. Two of them, HeLa and MCF-7, are human carcinogenic cells from cervical carcinoma and human breast cancer, respectively. A comparison with healthy cells was carried out with BGM cells which are monkey epithelial cells of renal origin. The behavior of complex II exhibits selectivity towards healthy cells, which is a promising feature for use in cancer treatment since it might reduce the side effects of most current therapies.
Databáze: Directory of Open Access Journals
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