| Autor: |
Hayat Ullah, Imad Uddin, Hafeeza Zafar Ali, Wagma Hassan, Gul Mehnaz, Laiba Maryam, Maliha Sarfraz, Muhammad Saleem Khan, Mohammad Shahidul Islam, Zainab M. Almarhoon, Rashid Iqbal, Muhammad Nabi |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Results in Chemistry, Vol 11, Iss , Pp 101832- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2211-7156 |
| DOI: |
10.1016/j.rechem.2024.101832 |
| Popis: |
The present study reports the design and synthesis of new benzimidazole-oxadiazole compounds as potent inhibitors of α-glucosidase and α-amylase. The synthesized molecules were characterized through different techniques such as 1HNMR, 13CNMR, HREI-MS and evaluated for their in vitro inhibitory activities against these enzymes. Among the compounds screened, compound 8 demonstrated the highest inhibitory activity against both α-glucosidase (IC50 = 11.60 µM) and α-amylase (IC50 = 6.20 µM). Molecular docking analyses were conducted to investigate the binding modes and interactions of the active compounds within the enzyme active sites. The results demonstrate that several benzimidazole-oxadiazole hybrids exhibited potent inhibitory effects on both α-glucosidase and α-amylase, suggesting their promise as antidiabetic agents. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
