Does prior immunization with measles, mumps, and rubella vaccines contribute to the antibody response to COVID-19 antigens?

Autor: Danesh Hassani, Mohammad Mehdi Amiri, Faezeh Maghsood, Vahid Salimi, Gholam Ali Kardar, Omid Barati, Seyed Mohammad Reza Hashemian, Mahmood Jeddi-Tehrani, Amir-Hassan Zarnani, Fazel Shokri
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Iranian Journal of Immunology, Vol 18, Iss 1, Pp 47-53 (2021)
Druh dokumentu: article
ISSN: 1735-1383
1735-367X
DOI: 10.22034/iji.2021.87990.1843
Popis: Background: Incidence and severity of SARS-CoV2 infection are significantly lower in children and teenagers proposing that certain vaccines, routinely administered to neonates and children may provide cross-protection against this emerging infection. Objective: To assess the cross-protection induced by prior measles, mumps and rubella (MMR) vaccinations against COVID-19. Methods: The antibody responses to MMR and tetanus vaccines were determined in 53 patients affected with SARS-CoV2 infection and 52 age-matched healthy subjects. Serum levels of antibodies specific for NP and RBD of SARS-CoV2 were also determined in both groups of subjects with ELISA. Results: Our results revealed significant differences in anti-NP (p
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