| Autor: |
Jules C. Hancox, Caroline S. Copeland, Stephen C. Harmer, Graeme Henderson |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of Molecular and Cellular Cardiology Plus, Vol 6, Iss , Pp 100049- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2772-9761 |
| DOI: |
10.1016/j.jmccpl.2023.100049 |
| Popis: |
Synthetic cannabinoid receptor agonists (SCRAs) have been associated with QT interval prolongation. Limited preclinical information on SCRA effects on cardiac electrogenesis results from the rapid emergence of new compounds and restricted research availability. We used two machine-learning-based tools to evaluate seven novel SCRAs' interaction potential with the hERG potassium channel, an important drug antitarget. Five SCRAs were predicted to have the ability to block the hERG channel by both prediction tools; ADB-FUBIATA was predicted to be a strong hERG blocker. ADB-5Br-INACA and ADB-4en-PINACA showed varied predictions. These findings highlight potentially proarrhythmic hERG block by novel SCRAs, necessitating detailed safety evaluations. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
