Membranoproliferative glomerulonephritis secondary to chronic myeloid leukemia

Autor: Subramanian Murali, Kilara Nalini, Manjunath R, Mysorekar Vijaya
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Saudi Journal of Kidney Diseases and Transplantation, Vol 21, Iss 4, Pp 738-741 (2010)
Druh dokumentu: article
ISSN: 1319-2442
Popis: The nephrotic syndrome (NS) is a well documented complication of hematological malignancies. However, chronic myeloid leukemia (CML) is rarely complicated by the NS, and it occurs usually after allogenic stem cell transplantation or interferon alpha therapy for CML. The NS as a complication of untreated CML is also rare. We report a 31-year-old patient who pre-sented with features of The NS. He was diagnosed to have CML one year ago and was on irre-gular treatment with imatinib mesylate. The renal biopsy and immunofluorescence revealed mem-branoproliferative glomerulonephritis type I. The patient was retreated with imatinib mesylate and the NS resolved gradually over three months. This maybe the third case in literature of mem-branoproliferative glomerulonephritis associated with CML.
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