Effects of Rivaroxaban on Biomarkers of Coagulation and Inflammation: A Post Hoc Analysis of the X-VeRT Trial

Autor: Paulus Kirchhof, Michael D. Ezekowitz, Yanish Purmah, Sonja Schiffer, Isabelle L. Meng, A. John Camm, Stefan H. Hohnloser, Anke Schulz, Melanie Wosnitza, Riccardo Cappato
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: TH Open, Vol 04, Iss 01, Pp e20-e32 (2020)
Druh dokumentu: article
ISSN: 2512-9465
DOI: 10.1055/s-0040-1701206
Popis: Introduction This X-VeRT (eXplore the efficacy and safety of once-daily oral riVaroxaban for the prevention of caRdiovascular events in patients with nonvalvular aTrial fibrillation scheduled for cardioversion) substudy evaluated the effects of treatment with rivaroxaban or a vitamin-K antagonist (VKA) on levels of biomarkers of coagulation (D-dimer, thrombin–antithrombin III complex [TAT] and prothrombin fragment [F1.2]) and inflammation (high sensitivity C-reactive protein [hs-CRP] and high-sensitivity interleukin-6 [hs-IL-6]) in patients with atrial fibrillation (AF) who were scheduled for cardioversion and had not received adequate anticoagulation at baseline (defined as, in the 21 days before randomization: no oral anticoagulant; international normalized ratio
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