Engineering a Ca++-Sensitive (Bio)Sensor from the Pore-Module of a Potassium Channel

Autor: Mattia Lorenzo DiFrancesco, Sabrina Gazzarrini, Cristina Arrigoni, Giulia Romani, Gerhard Thiel, Anna Moroni
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Sensors, Vol 15, Iss 3, Pp 4913-4924 (2015)
Druh dokumentu: article
ISSN: 1424-8220
DOI: 10.3390/s150304913
Popis: Signals recorded at the cell membrane are meaningful indicators of the physiological vs. pathological state of a cell and will become useful diagnostic elements in nanomedicine. In this project we present a coherent strategy for the design and fabrication of a bio-nano-sensor that monitors changes in intracellular cell calcium concentration and allows an easy read out by converting the calcium signal into an electrical current in the range of microampere that can be easily measured by conventional cell electrophysiology apparatus.
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