Low HDL-c levels at admission are associated with greater severity and worse clinical outcomes in patients with COVID-19 disease

Autor: Sandra Parra, Mireia Saballs, Mark DiNubile, Mireia Feliu, Simona Iftimie, Laia Revuelta, Raul Pavón, Alba Àvila, Susan Levinson, Antoni Castro
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Atherosclerosis Plus, Vol 52, Iss , Pp 1-8 (2023)
Druh dokumentu: article
ISSN: 2667-0895
DOI: 10.1016/j.athplu.2023.01.002
Popis: Background and aims: HDL particles may act to buffer host cells from excessive inflammatory mediators. The aim of this study is to investigate if the lipid profile provides a prognostic biomarker for COVID-19 outcomes. Methods: This was a prospective study of the characteristics of 125 adult COVID-19 patients with a lipid profile performed on the day of admission analyzed with regard to clinical outcomes. Results: Seventy-seven patients (61.2%) were men, with a mean age of 66.3 (15.6) years. 54.1% had bilateral pneumonia. The all-cause mortality rate during hospitalization was 20.8%. We found a direct association between more severe disease assessed by the WHO classification, admission to the ICU and death with more pronounced lymphopenia, higher levels of CRP, ferritin (p
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