Clinical use of Haemate® P in inherited von Willebrand’s disease: a cohort study on 100 Italian patients
| Autor: | Augusto B. Federici, Giancarlo Castaman, Massimo Franchini, Massimo Morfini, Ezio Zanon, Antonio Coppola, Annarita Tagliaferri, Elio Boeri, Maria Gabriella Mazzucconi, Gina Rossetti, Pier Mannuccio Mannucci |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | Haematologica, Vol 92, Iss 7 (2007) |
| Druh dokumentu: | article |
| ISSN: | 0390-6078 1592-8721 |
| DOI: | 10.3324/haematol.11124 |
| Popis: | Background and Objectives Plasma-derived concentrates containing von Willebrand factor and factor VIII (VWF/FVIII concentrates) are the mainstay of treatment of patients with inherited von Willebrand’s disease (VWD) who are unresponsive or have a contraindication to desmopressin (DDAVP) therapy. Only a few clinical studies are available on the use of these VWF/FVIII concentrates in large numbers of cases and within the same country. The aim of our study was to collect retrospective data on the efficacy and safety of Haemate® P (CSL Behring, Marburg, Germany) in a large cohort of well-characterized VWD patients after the introduction of the guidelines for VWD management in Italy.Design and Methods A retrospective survey of data records was organized among ten Italian Hemophilia Centers in order to retrieve information on the clinical use of Haemate® P. Data on 100 VWD patients (44 males and 56 females, median age 41.5, range 2–87 years) were available relating to the period from January 2002 to December 2004. All patients were diagnosed according to the criteria proposed by the Italian guidelines for VWD management.Results Of the 100 VWD patients enrolled, 23 had type 1 VWD, 40 had type 2 (2A=7, 2B=11, 2M=9, 2M Vicenza=13) and 37 had type 3. Seventy-one percent were severely affected, as shown by VWF:RCo levels |
| Databáze: | Directory of Open Access Journals |
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