Pathogenic diversity of RNA variants and RNA variation-associated factors in cancer development

Autor: Hee Doo Yang, Suk Woo Nam
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Experimental and Molecular Medicine, Vol 52, Iss 4, Pp 582-593 (2020)
Druh dokumentu: article
ISSN: 1226-3613
2092-6413
DOI: 10.1038/s12276-020-0429-6
Popis: Cancer: Mixed messages fuel tumor progression A single gene can generate a variety of RNA products, and changes in this final RNA output can directly contribute to cancer onset and progression. The initial transcription of each DNA sequence yields a raw RNA strand that subsequently undergoes a variety of modification processes that shape its function. Hee Doo Yang and Suk Woo Nam, The Catholic University of Korea, Seoul, have reviewed the potential impact of these mechanisms on malignancy. Some cancers, for example, express RNA sequences that have been inappropriately edited by an enzymatic process called splicing, yielding abnormal RNAs that drive metastasis. Other tumors contain RNAs with atypical chemical modifications, or in which individual nucleotides have been enzymatically converted into other nucleotides. A deeper understanding of these RNA alterations and their impacts could lead to more effective and targeted cancer treatments.
Databáze: Directory of Open Access Journals
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