| Autor: |
Kevin S. Martin, Cristian Soldi, Kellan N. Candee, Hiromi I. Wettersten, Robert H. Weiss, Jared T. Shaw |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 260-264 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1860-5397 |
| DOI: |
10.3762/bjoc.9.31 |
| Popis: |
A concise synthesis of benzimidazole-substituted β-amido-amide LLW62 is presented. The original synthesis of compounds related to LLW62 was developed on Rink resin as part of a “one-bead, one-compound” combinatorial approach for on-bead screening purposes. The current synthesis is carried out in solution and is amenable to scale-up for follow-up studies on LLW62 and investigations of related structures. The key step involves the use of a β-amino acid-forming three-component reaction (3CR), the scope of which defines its role in the synthetic strategy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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