Inhibitory activities of microalgal extracts against Epstein-Barr Virus (EBV) antigen expression in lymphoblastoid cells
| Autor: | Koh Yih Yih, Chu Wan Loy, Phang Siew Moi, Mohamed Shar Mariam, Rakesh Naidu, Lai Pey Jiun, Ling Shui Nyuk, Mak Joon Wah, Lim Patricia Kim Chooi, Pauline Balraj, Khoo Alan Soo Beng |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Archives of Biological Sciences, Vol 66, Iss 3, Pp 1009-1024 (2014) |
| Druh dokumentu: | article |
| ISSN: | 0354-4664 1821-4339 |
| DOI: | 10.2298/ABS1403009K |
| Popis: | The inhibitory activities of microalgal extracts against the expression of three EBV antigens, latent membrane protein (LMP)1, Epstein-Barr nuclear antigen (EBNA)1 and Z Epstein-Barr reactivation activator (ZEBRA) were assessed by immunocytochemistry. The observation that the methanol extracts and their fractions from Ankistrodesmus convolutus, Synechococcus elongatus and Spirulina platensis exhibited inhibitory activity against EBV proteins in three Burkitt’s lymphoma cell lines at concentrations as low as 20 μg/ml suggests that microalgae could be a potential source of antiviral compounds against EBV. |
| Databáze: | Directory of Open Access Journals |
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