| Autor: |
Schmidt-Wolf, Ingo G.H., Strehl, John, Frank, Susanne, Gütgemann, Stefan |
| Jazyk: |
German<br />English |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
GMS German Medical Science, Vol 5, p Doc07 (2007) |
| Druh dokumentu: |
article |
| ISSN: |
1612-3174 |
| Popis: |
Background: Until now, cytokine-induced killer (CIK) cells were assumed to be part of the type I natural killer T (NKT) cell population, but it was not yet investigated if this is correct. Methods: For analysis, CIK cells were generated by various culture conditions. Human type I NKT cells express a T cell receptor (TCR) composed of an invariant Vα24-JαQ chain combined with one of several Vβ chains. The Vα24 is a reliable marker for the presence of these TCRs. Results: While comparing cultures stimulated with different substances, we observed the lack of any Vα24 on the surface of CIK culture cells. Conclusion: We conclude that CIK cells do not belong to the type I NKT cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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