Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride.

Autor: P Kanda, M A Wells
Jazyk: angličtina
Rok vydání: 1981
Předmět:
Zdroj: Journal of Lipid Research, Vol 22, Iss 5, Pp 877-879 (1981)
Druh dokumentu: article
ISSN: 0022-2275
DOI: 10.1016/S0022-2275(20)37361-2
Popis: A simplified procedure for the synthesis of short acyl chain phosphatidylcholines is described. A mixed fatty acid-trifluoroacetic anhydride is used to acylate sn-glycero-3-phosphocholine (GPC) which has been dissolved in trifluoroacetic acid. Yields exceeding 70% are achieved in 30-min reaction time using 1.5 to 2.0 equivalents of mixed anhydride per, GPC hydroxyl. This allows a more economical use of labeled short chain acids.
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