| Autor: |
Erika Giorgia Quaranta, Alice Fusaro, Edoardo Giussani, Valeria D'Amico, Maria Varotto, Matteo Pagliari, Maria Teresa Giordani, Maira Zoppelletto, Francesca Merola, Antonio Antico, Paola Stefanelli, Calogero Terregino, Isabella Monne |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
International Journal of Infectious Diseases, Vol 122, Iss , Pp 444-448 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1201-9712 |
| DOI: |
10.1016/j.ijid.2022.06.023 |
| Popis: |
Objectives: Intra-host SARS-CoV-2 evolution during chronic infection in immunocompromised hosts has been suggested as being the possible trigger of the emergence of new variants. Methods: Using a deep sequencing approach, we investigated the SARS-CoV-2 intra-host genetic evolution in a patient with HIV over a period of 109 days. Results: Sequencing of nasopharyngeal swabs at three time points demonstrated dynamic changes in the viral population, with the emergence of 26 amino acid mutations and two deletions, 57% of them in the Spike protein. Such a combination of mutations has never been observed in other SARS-CoV-2 lineages detected so far. Conclusion: Our data confirm that persistent infection in certain immunocompromised individuals for a long time may favor the dangerous emergence of new SARS-CoV-2 variants with immune evasion properties. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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