Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model

Autor: Song-Hee Han, Sung-June Kim, Young Won Yun, Sang Yoon Nam, Hu-Jang Lee, Beom-Jun Lee
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Laboratory Animal Research, Vol 34, Iss 1, Pp 37-43 (2018)
Druh dokumentu: article
ISSN: 2233-7660
DOI: 10.5625/lar.2018.34.1.37
Popis: Abstract This study was performed to investigate the effect of a concentrate of fermented wild ginseng root culture (HLJC0701) on memory improvement in the scopolamine (SPL)-induced memory-deficient mouse model. Eight-week-old male ICR mice were used to evaluate the protective effect of HLJC0701 against the SPL-induced memory loss animal model. The Morris water maze test, which measures hippocampus-dependent learning ability, and the Y-maze test, a short-term memory assessment test, were performed and related markers were analyzed. HLJG0701-treated groups displayed significantly reduced acetylcholinesterase activity and increased acetylcholine level compared with the SPL-administered group (SPL-G) (P
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