Protein lysine crotonylation in cellular processions and disease associations

Autor: Hongling Zhao, Yang Han, Pingkun Zhou, Hua Guan, Shanshan Gao
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Genes and Diseases, Vol 11, Iss 5, Pp 101060- (2024)
Druh dokumentu: article
ISSN: 2352-3042
DOI: 10.1016/j.gendis.2023.06.029
Popis: Protein lysine crotonylation (Kcr) is one conserved form of posttranslational modifications of proteins, which plays an important role in a series of cellular physiological and pathological processes. Lysine ε-amino groups are the primary sites of such modification, resulting in four-carbon planar lysine crotonylation that is structurally and functionally distinct from the acetylation of these residues. High levels of Kcr modifications have been identified on both histone and non-histone proteins. The present review offers an update on the research progression regarding protein Kcr modifications in biomedical contexts and provides a discussion of the mechanisms whereby Kcr modification governs a range of biological processes. In addition, given the importance of protein Kcr modification in disease onset and progression, the potential viability of Kcr regulators as therapeutic targets is elucidated.
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