| Autor: |
Jin-Yong Chung, Yongjie Ma, Dingguo Zhang, Hayden H. Bickerton, Eric Stokes, Sweta B. Patel, Hubert M. Tse, Joseph Feduska, Rob S. Welner, Ronadip R. Banerjee |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 26, Iss 4, Pp 106439- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2023.106439 |
| Popis: |
Summary: Pancreatic β-cell mass expands during pregnancy and regresses in the postpartum period in conjunction with dynamic metabolic demands on maternal glucose homeostasis. To understand transcriptional changes driving these adaptations in β-cells and other islet cell types, we performed single-cell RNA sequencing on islets from virgin, late gestation, and early postpartum mice. We identified transcriptional signatures unique to gestation and the postpartum in β-cells, including induction of the AP-1 transcription factor subunits and other genes involved in the immediate-early response (IEGs). In addition, we found pregnancy and postpartum-induced changes differed within each endocrine cell type, and in endothelial cells and antigen-presenting cells within islets. Together, our data reveal insights into cell type–specific transcriptional changes responsible for adaptations by islet cells to pregnancy and their resolution postpartum. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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