| Autor: |
Vahid Hoghooghi, Alexandra L. Palmer, Ariana Frederick, Yulan Jiang, Jessica E. Merkens, Anjali Balakrishnan, Trisha M. Finlay, Anders Grubb, Efrat Levy, Paul Gordon, Frank R. Jirik, Minh Dang Nguyen, Carol Schuurmans, Frank Visser, Shannon E. Dunn, Shalina S. Ousman |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Cell Reports, Vol 33, Iss 1, Pp 108236- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2211-1247 |
| DOI: |
10.1016/j.celrep.2020.108236 |
| Popis: |
Summary: The cysteine protease inhibitor Cystatin C (CST3) is highly expressed in the brains of multiple sclerosis (MS) patients and C57BL/6J mice with experimental autoimmune encephalomyelitis (EAE; a model of MS), but its roles in the diseases are unknown. Here, we show that CST3 plays a detrimental function in myelin oligodendrocyte glycoprotein 35-55 (MOG35-55)-induced EAE but only in female animals. Female Cst3 null mice display significantly lower clinical signs of disease compared to wild-type (WT) littermates. This difference is associated with reduced interleukin-6 production and lower expression of key proteins (CD80, CD86, major histocompatibility complex [MHC] II, LC3A/B) involved in antigen processing, presentation, and co-stimulation in antigen-presenting cells (APCs). In contrast, male WT and Cst3−/− mice and cells show no differences in EAE signs or APC function. Further, the sex-dependent effect of CST3 in EAE is sensitive to gonadal hormones. Altogether, we have shown that CST3 has a sex-dependent role in MOG35-55-induced EAE. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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