Efficacy of ivabradine in combination therapy for complicated acute coronary syndrome in patients with type 2 diabetes mellitus
| Autor: | Arkadiy Ivanovich Kondrat'ev, Vladimir Terent'evich Dolgikh, Aleksandr Olegovich Stotskiy, A I Kondratyev, V T Dolgikh, A O Stotsky |
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| Jazyk: | ruština |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Терапевтический архив, Vol 0, Iss 1, Pp 27-31 (2010) |
| Druh dokumentu: | article |
| ISSN: | 0040-3660 2309-5342 |
| Popis: | Aim: To study the effect of ivabradine (coraxan, Servier) as part of combination therapy on the clinical manifestations of acute left ventricular failure (ALVF) in Braunwald class II-IIIB unstable angina in patients with type 2 diabetes mellitus (T2DM). Subjects and methods. Thirty-six T2DM patients (mean age 56 ± 4.3 years) with a diagnosis of acute coronary syndrome were examined. Eighteen healthy individuals were examined as an age- and gender-matched control group. Metabolic, hemodynamic, and electrophysiological parameters were studied in all the patients on hospital stay days 1 and 5. Results. Ivabradine used in combination therapy for unstable angina caused reductions in the clinical manifestations of ALVF, heart rate, the number of myocardial ischemic episodes. In the ivabradine-treated patients, left ventricular ejection fraction showed a significant trend for increase. No adverse reactions were recorded. Conclusion. Ivabradine therapy demonstrated antiischemic and antianginal efficiencies and a good tolerability, without leading to the development of tolerance and without being followed by the development of the withdrawal syndrome. |
| Databáze: | Directory of Open Access Journals |
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