Genetic alterations of tumor suppressor gene in sporadic colorectal cancers

Autor: Hadžiavdić Vesna, Eminović Izet, Hamidović Hajrija, Pavlović-Čalić Nada
Jazyk: English<br />Serbian
Rok vydání: 2012
Předmět:
Zdroj: Glasnik Antropološkog Društva Srbije, Vol 2012, Iss 47, Pp 155-162 (2012)
Druh dokumentu: article
ISSN: 1820-7936
1820-8827
DOI: 10.5937/gads1247155H
Popis: Colorectal cancer with its frequency, high mortality rate as well as many etiological unknowns is a challenge to contemporary science. Finally, genetic information could be used in near future for prevention of colorectal cancer, its early diagnosis and selection for the most suitable hospital treatment. In this study, we analysed genetic alterations of tumor suppressor genes and the possibility of quick and efficient screening method for identification of colorectal cancer. The study consisted of 54 samples of tumor and surrounding healthy tissue of patients with colorectal cancer, which is clasificated according to Bethesda and Amsterdams criterias. The investigation showed that genetic alterations of tumor suppressor gene NM 23 were present in 19/35 (54,29%) samples, and tumor suppressor gene p53 in 18/35 (51,43%), APC in 18/35 (51,43%), DCC2 tumor suppressor gene in 12/35 (34,29%), tumor suppressor gene RB1 in 8 /35 (22, 86%) and DCC 1 in 10/35 ( 28,57%) tumor tissue.
Databáze: Directory of Open Access Journals