| Autor: |
E. A. Svetoch, A. I. Borzilov, B. V. Eruslanov, O. V. Korobova, T. I. Kombarova, V. P. Levchuk, M. G. Teymurazov, Y. G. Stepanshin, L. I. Marinin, I. A. Dyatlov |
| Jazyk: |
ruština |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Антибиотики и Химиотерапия, Vol 56, Iss 9-10, Pp 13-18 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
0235-2990 |
| Popis: |
The therapeutic efficacy of enterocin S760, a broad spectrum antimicrobial peptide produced by Enterococcus faecium LWP760 was tested on mice infected with Bacillus anthracis M-71 to induce anthrax (second Tsenkovsky's vaccine). Intraperitoneal four-, two- or one-fold administration of the peptide in a dose of 25 mg/kg for 10 days for prophylactic (1 hour after the contamination) and therapeutic (24 hours after the contamination) purposes prevented or cured the infection in 90-100% of the mice versus the 100-percent lethality in the control (untreated animals). The antimicrobial activity of enterocin S760 against B.anthracis M-71 in vivo correlated with activity in vitro. Enterocin S760 is considered a novel promising antimicrobial for the treatment of grampositive and gramnegative infections. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
