Greening automation: Wash and Re-use of disposable 384-well liquid handling tips to enable sustainable high-throughput vaccine development

Autor: Brittney Pedrazzi, Aleksandr Treyer, Rachael Cohen, Amy Bowman, Jillian Acevedo-Skrip, Kristine Kearns, David Westover, John W. Loughney
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: SLAS Technology, Vol 28, Iss 5, Pp 375-379 (2023)
Druh dokumentu: article
ISSN: 2472-6303
DOI: 10.1016/j.slast.2023.06.003
Popis: Laboratory automation uses large amounts of plastic consumables, generating substantial single-use plastic waste. Automated ELISAs are an indispensable analytical tool in vaccine formulation and process development. Current workflows, however, rely on disposable liquid handling tips. In progress toward sustainability, we developed workflows for washing 384-well format liquid handling tips, using nontoxic reagents, for re-use during ELISA testing. We estimate that this workflow reduces plastic and cardboard waste in our facility by 989 kg/year and 202 kg/year, respectively, without introducing new chemicals into our waste steam.
Databáze: Directory of Open Access Journals