Hidden diagnosis of multiple endocrine neoplasia-1 unraveled during workup of virilization caused by adrenocortical carcinoma

Autor:	Sandeep Kharb, Aditi Pandit, Abhay Gundgurthi, M K Garg, K S Brar, N Kannan, Reena Bharwaj
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	Adrenocortical carcinoma Cushing′s syndrome multiple endocrine neoplasia-1 virilizing syndrome Diseases of the endocrine glands. Clinical endocrinology RC648-665 Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	Indian Journal of Endocrinology and Metabolism, Vol 17, Iss 3, Pp 514-518 (2013)
Druh dokumentu:	article
ISSN:	2230-8210 2230-9500
DOI:	10.4103/2230-8210.111672
Popis:	Multiple endocrine neoplasia-1 (MEN1) is an autosomal dominant syndrome with classic triad of parathyroid hyperplasia, pancreatic neuroendocrine tumors, and pituitary adenomas. Other recognized manifestations include carcinoid, cutaneous or adrenocortical tumors. It is commonly presented with clinical features related to parathyroid, pancreas or pituitary lesions. Here, we have presented a case that had virilization and biochemical Cushing′s syndrome due to adrenocortical carcinoma as presenting feature of MEN1. Cushing′s syndrome in MEN1 is an extremely rare and usually late manifestation and most cases are due to corticotropin-producing pituitary adenomas. Although Cushing′s syndrome generally develops years after the more typical manifestations of MEN1 appear, it may be the primary manifestation of MEN1 syndrome particularly when related to adrenal adenoma or carcinoma.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/45e637d25caf4d45ae6ee4bbb0b991ed Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF