Urine high–sensitive troponin I in children cannot offer an applicable alternative to serum

Autor: Matija Bakoš, Daniel Dilber, Anamarija Jazbec, Tomo Svaguša, Ana-Meyra Potkonjak, Duje Braovac, Željko Đurić, Andrea Radeljak, Ana Lončar Vrančić, Hrvoje Vraneš, Slobodan Galić, Milivoj Novak, Ingrid Prkacin
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Druh dokumentu: article
ISSN: 2297-055X
DOI: 10.3389/fcvm.2024.1391434
Popis: IntroductionIn children, congenital heart defects represent the primary cause of increased serum troponin I. The elimination process of cardiac troponin I from the bloodstream and the factors influencing this process remain unknown. The objective of this study was to explore the role of troponin I as an indicator of cardiac damage in children both in serum and urine, a concept previously investigated in adults.MethodsOur prospective study involved 70 children under 24 months of age. The first group underwent ventricular septal defect repair, while the second group involved children who had undergone partial cavopulmonary anastomosis. For these groups, urine and serum troponin I were assessed on four occasions. The third group, consisting of healthy children, underwent a single measurement of urine troponin I.ResultsSerum troponin I values exhibited an expected elevation in the early postoperative period, followed by a return to lower levels. Significantly higher concentrations of serum troponin I were observed in the first group of children (p
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