Comparative Metagenomic Analysis of Biosynthetic Diversity across Sponge Microbiomes Highlights Metabolic Novelty, Conservation, and Diversification

Autor: Catarina Loureiro, Anastasia Galani, Asimenia Gavriilidou, Maryam Chaib de Mares, John van der Oost, Marnix H. Medema, Detmer Sipkema
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: mSystems, Vol 7, Iss 4 (2022)
Druh dokumentu: article
ISSN: 2379-5077
DOI: 10.1128/msystems.00357-22
Popis: ABSTRACT Marine sponges and their microbial symbiotic communities are rich sources of diverse natural products (NPs) that often display biological activity, yet little is known about the global distribution of NPs and the symbionts that produce them. Since the majority of sponge symbionts remain uncultured, it is a challenge to characterize their NP biosynthetic pathways, assess their prevalence within the holobiont, and measure the diversity of NP biosynthetic gene clusters (BGCs) across sponge taxa and environments. Here, we explore the microbial biosynthetic landscapes of three high-microbial-abundance (HMA) sponges from the Atlantic Ocean and the Mediterranean Sea. This data set reveals striking novelty, with
Databáze: Directory of Open Access Journals