| Autor: |
Andrew Hagner, Wisoo Shin, Sarthak Sinha, Whitney Alpaugh, Matthew Workentine, Sepideh Abbasi, Waleed Rahmani, Natacha Agabalyan, Nilesh Sharma, Holly Sparks, Jessica Yoon, Elodie Labit, John Cobb, Ina Dobrinski, Jeff Biernaskie |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 23, Iss 4, Pp - (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2020.101019 |
| Popis: |
Summary: The adult hair follicle (HF) undergoes successive regeneration driven by resident epithelial stem cells and neighboring mesenchyme. Recent work described the existence of HF dermal stem cells (hfDSCs), but the genetic regulation of hfDSCs and their daughter cell lineages in HF regeneration remains unknown. Here we prospectively isolate functionally distinct mesenchymal compartment in the HF (dermal cup [DC; includes hfDSCs] and dermal papilla) and define the transcriptional programs involved in hfDSC function and acquisition of divergent mesenchymal fates. From this, we demonstrate cross-compartment mesenchymal signaling within the HF niche, whereby DP-derived R-spondins act to stimulate proliferation of both hfDSCs and epithelial progenitors during HF regeneration. Our findings describe unique transcriptional programs that underlie the functional heterogeneity among specialized fibroblasts within the adult HF and identify a novel regulator of mesenchymal progenitor function during tissue regeneration. : Biological Sciences; Developmental Biology; Stem Cells Research Subject Areas: Biological Sciences, Developmental Biology, Stem Cells Research |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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