Novel role of lncRNAs regulatory network in papillary thyroid cancer

Autor: Yuanhao Su, Lin Mei, Tiantian Jiang, Zhidong Wang, Yuanyuan Ji
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101674- (2024)
Druh dokumentu: article
ISSN: 2405-5808
DOI: 10.1016/j.bbrep.2024.101674
Popis: Papillary thyroid cancer (PTC) is the most common endocrine malignancy. The incidence of PTC has increased annually worldwide. Thus, PTC diagnosis and treatment attract more attention. Noncoding RNAs (lncRNAs) play crucial roles in PTC progression and act as prognostic biomarkers. Moreover, microRNAs (miRNAs) and epithelial-mesenchymal transition (EMT)-associated proteins have potential biomarkers for diagnosing and treating PTC. However, the correlation of lncRNAs with miRNAs and EMT-associated proteins needs further clarification. The present review highlights the recent advances of lncRNAs in PTC. We significantly summarized the two molecular regulatory mechanisms in PTC progress, including lncRNAs-miRNAs-protein signaling axes and lncRNAs-EMT pathways. This review will help our understanding of the association between lncRNAs and PTC and may assist us in evaluating the prognosis for PTC patients. Taken together, targeting the lncRNAs regulatory network has promising applications in diagnosing and treating PTC.
Databáze: Directory of Open Access Journals