Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
| Autor: | Behnam Nabet, Fleur M. Ferguson, Bo Kyung A. Seong, Miljan Kuljanin, Alan L. Leggett, Mikaela L. Mohardt, Amanda Robichaud, Amy S. Conway, Dennis L. Buckley, Joseph D. Mancias, James E. Bradner, Kimberly Stegmaier, Nathanael S. Gray |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 46191739 |
| DOI: | 10.1038/s41467-020-18377-w |
| Popis: | The dTAG system is used to rapidly deplete tagged target proteins in vitro and in vivo, but there are context- and protein-specific differences in its effectiveness. Here, the authors develop a second generation dTAG molecule that can degrade previously recalcitrant target proteins in cells and mice. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|