| Autor: |
Marina Guitton Rodrigues, Paula Marcela Vilela Castro, Tiago Careli de Almeida, Bruno Carrijo Cunha, Fernanda Ribeiro Danziere, Francisco Antonio Sergi Filho, Beimar Edmundo Zeballos Sempertegui, Juan Rafel Branez, Leonardo Toledo Mota, Marcelo Perosa de Miranda, Regina Gomes dos Santos, e Tércio Genzini |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Transplantation Reports, Vol 5, Iss 3, Pp 100054- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2451-9596 |
| DOI: |
10.1016/j.tpr.2020.100054 |
| Popis: |
Despite the malformations commonly associated with Down Syndrome, the average life expectancy of individuals nowadays may reach 60-70 years of age. With these increased survival rates, the spectrum of diseases reported in these patients has been growing, particularly autoimmune diseases. This report describes a 44-year-old patient with Down Syndrome with a high degree of family dependence and end-stage liver disease (MELD-Na 38) caused by overlapping Primary Sclerosing Cholangitis and Autoimmune Hepatitis, who needed Liver Transplantation. Here, we point out two relevant aspects: the overlap of rare autoimmune diseases in patients with Trisomy 21 and the performance of Liver Transplantation in these patients. We then highlight the ethical dilemma between organ scarcity and the use of the graft in patients with neurocognitive disorders. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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