TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine

Autor: C. C. Bain, J. Montgomery, C. L. Scott, J. M. Kel, M. J. H. Girard-Madoux, L. Martens, T. F. P. Zangerle-Murray, J. Ober-Blöbaum, D. Lindenbergh-Kortleve, J. N. Samsom, S. Henri, T. Lawrence, Y. Saeys, B. Malissen, M. Dalod, B. E. Clausen, A. McI. Mowat
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-017-00658-6
Popis: Developmental cues for the different dendritic cell (DC) subsets in the intestine are yet to be defined. Here the authors show that TGFβR1 signalling is needed for development of CD103+CD11b+ intestinal DCs from CD103−CD11b+ cells and that they contribute to the generation of Th17 and regulatory T cells
Databáze: Directory of Open Access Journals