| Autor: |
Tal Saban, Liat Shargian, Maya Eiger-Moscovitch, Susan Prockop, Ekatarina Doubrovina, Moshe Yeshurun, Michal Kramer |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Ophthalmology, Vol 3 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2674-0826 |
| DOI: |
10.3389/fopht.2023.1131674 |
| Popis: |
PurposeWe hereby describe a case of persistent cytomegalovirus (CMV) viremia and retinitis following allogeneic hematopoietic cell transplantation (HCT) that was successfully treated with infusion of CMV-specific cytotoxic T lymphocytes (CTL) despite previous treatment with Epstein Bar Virus (EBV) -specific CTL, which occurred 5 months earlier.ObservationsFollowing several anti- viral medication treatment trials that failed to eradicate the infectious process, the patient was treated with infusions of CMV-CTL from a biobank of cryopreserved virus-specific cells. Shortly after the first infusion, a remarkable response was noted. A few days after the second infusion, the retinitis resolved completely. No recurrence was noted at the one-year follow-up, and there was no evidence of GVHD.Conclusions and importanceThe case is unique for two reasons: use of virus-specific CTL for an indication of CMV retinitis; and successive administration, in the same patient, of third-party virus-specific CTL to treat two different infections (Epstein-Barr virus and cytomegalovirus) on two separate occasions following hematopoietic cell transplantation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
